Publications

Advances in 3D neuronal microphysiological systems: towards a functional nervous system on a chip

Publications

January 12, 2021 AxoSim’s Research Scientist Wesley Anderson published a review paper with Springer Nature’s In Vitro Cellular & Developmental Biology – Animal on advances in 3D neuronal microphysiological systems, the technology that powers AxoSim’s […]

Fabrication and Characterization of 3D Printed, 3D Microelectrode Arrays for Interfacing with a Peripheral Nerve-on-a-Chip

Publications

December 10, 2020 We present a nontraditional fabrication technique for the realization of three-dimensional (3D) microelectrode arrays (MEAs) capable of interfacing with 3D cellular networks in vitro. The technology uses cost-effective makerspace microfabrication techniques to fabricate the 3D […]

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Publications

February 21. 2020 Selective serotonin reuptake inhibitors (SSRIs) are frequently used to treat depression during pregnancy. Various concerns have been raised about the possible effects of these drugs on fetal development. Current developmental neurotoxicity (DNT) […]

Modeling chemotherapy-induced peripheral neuropathy using a nerve-on-a-chip microphysiological system

Publications

July 15, 2020 Organ-on-a-chip devices that mimic in vivo physiology have the potential to identify effects of chemical and drug exposure in early preclinical stages of drug development while relying less heavily on animal models. We designed […]

Rotenone exerts developmental neurotoxicity in a human brain spheroid model

Publications

September 1, 2018 Growing concern suggests that some chemicals exert (developmental) neurotoxicity (DNT and NT) and are linked to the increase in incidence of autism, attention deficit and hyperactivity disorders. The high cost of routine […]

Microengineered peripheral nerve-on-a-chip for preclinical physiological testing

Publications

March 27, 2015 The use of advanced in vitro testing is a powerful tool to develop predictive cellular assays suitable for improving the high attrition rates of novel pharmaceutical compounds. A microscale, organotypic model of […]

A Human Brain Microphysiological System Derived from Induced Pluripotent Stem Cells to Study Neurological Diseases and Toxicity

Publications

July 16, 2018 Human in vitro models of brain neurophysiology are needed to investigate molecular and cellular mechanisms associated with neurological disorders and neurotoxicity. We have developed a reproducible iPSC-derived human 3D brain microphysiological system […]

Engineering a 3D functional human peripheral nerve in vitro using the Nerve-on-a-Chip platform

Publications

June 20, 2019 Development of “organ-on-a-chip” systems for neuroscience applications are lagging due in part to the structural complexity of the nervous system and limited access of human neuronal & glial cells. In addition, rates […]