Our Services

AXOSIM PARTNERS WITH PRECLINICAL SCIENTISTS TO SOLVE ADVANCED PROBLEMS

We provide predictive human data that helps toxicologists and discovery scientists make informed decisions as they advance from high-throughput in vitro assays all the way to IND-enabling studies. AxoSim’s SimLab provides services that help researchers throughout the drug development process.

Drug candidate selection is currently difficult and imperfect. Animal testing and other preclinical models are too often not predictive in humans. Selecting the wrong candidate can result in major losses of money, time, and resources.

AxoSim’s industry leading biomimetic platforms enable us to work with our clients to apply predictive human data to identify better drug candidates, earlier, more accurately and far more efficiently.

We aim to be your neurology and toxicology partner in advancing your drug development programs.

Monoculture and Co-Culture Models

Learn more about your drug candidates’ target activity through our advanced neuronal monoculture and co-culture models which are customizable based on your specific goals. Our team of neuroscientists and biomedical engineers use state-of-the-art cell culture methods to answer your hypotheses faster. Additionally, Microelectrode Array and High-Content Imaging are available. Microelectrode Array characterizes functional differences in neuronal activity and network characteristics. Outputs include: firing rate, burst rate, burst duration, interburst interval, and network synchronization. High-content imaging explores changes in neurite outgrowth, cell viability, and receptor and protein expression. Metrics include: neurite length, neurite branching, cell density, live/dead, and percent expression.

Peripheral Neurotoxicity Assay with Schwann Cells (Human)

Our human peripheral neuropathy assay uses primary human Schwann Cells and iPSC-derived peripheral neurons to recapitulate peripheral neuropathy in vitro. Assays available include high content-imaging and microelectrode array based readouts.

Peripheral Neurotoxicity Assay with Microglia (Rat)

Our rat peripheral neurotoxicity assay utilizes a co-culture of primary dorsal root ganglion and microglia to recapitulate peripheral immuno-neurotoxicity in vitro. Assays available include high content-imaging and microelectrode array based readouts.

Motor Neurotoxicity Assay (Human)

Human iPSC-derived motor neurons are cultured to create a motor neuron-specific system. Assays available include neurite outgrowth high content-imaging and microelectrode array based readouts.

ALS Assay with SOD1 Patient-Derived Motor Neurons and Astrocytes (Human)

Our ALS assay utilizes SOD1 patient-derived motor neurons and astrocytes to examine interactions within the co-culture system related to ALS pathology. Assays include high content imaging, both neurite outgrowth and protein inclusion, as well as microelectrode array readouts (beta).

Custom Disease Models

Our co-culture assays can be customized to meet your company’s specific needs. If you would like to learn more about a neurological assay developed using a patient-derived cell line, please email us at bd@axosim.com.

NerveSim® and BrainSim®

Need to explore mechanism of action to select a better candidate to progress into in vivo studies? Our NerveSim® and BrainSim® are the only models in the industry to provide high levels of physiologically-relevant myelination and we use the exact same metrics used by clinicians to diagnose and track disease progression, nerve conduction velocity and histomorphometry. Our models provide clinically predictive data faster, helping take the guessing out of candidate selection.

Toxicology

Understand mechanism of action by correlating functional nerve conduction measurements (NCV) and structural histomorphometry.

Diseases

Study patient derived and genetically modified co-culture models of neurodegenerative diseases where electrical and structural pathology are critical.

Custom Model

Have you had a clinical candidate show different results across species? Use our human model to make the case for why the accuracy of your candidate should be trusted from a mechanism of action perspective.