We provide both peripheral and central nervous system models for toxicology and drug screening assays. Whether you are in need of a screening to determine toxic side effects of lead compounds with our SimTox services or want to test protection and recovery potential with our SimDiscovery services.
Investigate potential neurotoxic effects of your candidates in the peripheral nervous system and examine mechanism of action by correlating of clinically translational electrophysiology, including nerve conduction measurements (NCV),structural histomorphometry through neurodegeneration metrics using immunohistochemistry (IHC), and transcriptomics in our NerveSim® platform.
Evaluate drug toxicity in the central nervous system with our BrainSim® model using IHC, transcriptomics, proteomics, and supernatant analysis to potential toxicity liabilities in your experimental compounds.
Screen for potential seizurogenic side effects with our additional central nervous system microBrain™ model with clinically translational network activity using calcium imaging as well as cell viability, IHC, ‘omics, and supernatant analysis.
Utilize our platforms to investigate drug candidates for peripheral and central nervous system conditions that can be mimicked in our NerveSim®, BrainSim® and microBrain™ platforms. By first inducing injury or disease phenotypes we can then co-administer in a study designed to address protection or recovery potential to look at efficacy of various drug candidates. The ability to measure drug efficacy in a human in-vitro model allows for more cost effective and efficient analysis of your drug candidates therapeutic potential.
One of the top reasons I enjoy working on NerveSim® is the novelty. There simply isn’t anything like it currently available.